Another example for an important event in the development of modern neuro-ethics was the case of Phineas Gage, who, in the middle of the 19th century, suffered from a heavy accident. Because of the accident, he was left with permanent damage to his brain. An iron rod destroyed parts of his orbitofrontal and prefrontal cortex. Although he survived the accident and did not receive any impairment to his memory, perception, intelligence or similar cognitive capacities, his personality changed – especially, his moral evaluations of situations, circumstances and ethical problems. This case forms a benchmark in the examination of the biological understanding of morality.